10.11.12

Echinacea: a natural interferon ?


Common name: purple coneflower.
Botanical names: Echinacea angustifolia, E. pallida, E. purpurea, family Asteraceae.
English names: Echinacea, American cone flower, snakeroot.


Parts used: Roots (E. pallida, E. angustifolia, E. purpurea) and aerial parts (E. purpurea).

Habitat and origin: all species of coneflowers are native to North America. Three of them have the same medicinal value. Natural stands of Echinacea mainly colonized the American Great Plains without crossing the Canadian border to the north, or to reach the Mexican border in the south. Today, they are cultivated in all temperate climates, in sunny locations where the soil is rich and well drained.


History:
Echinacea has a long and intriguing history of use. For hundreds of years, the Plains Indians used it as an antiseptic, an analgesic, and to treat poisonous insect and snakebites, toothaches, sore throat, wounds and communicable diseases such as mumps, smallpox, and measles. It was also used by the Cheyenne, Choctaw, Comanche, Dakota, Meskawaki Fox, Pawnee, Sioux, and Omaha tribes.  It was used as a treatment for saddle sores on horses. Echinacea became known in Europe around 1895. Many research studies done by doctors in Germany indicated that echinacea is effective primarily by increasing the number of white blood cells, thus boosting the immune system and thereby increasing the body's ability to fight infections.
active substances
Alkaloids indolizidiniques derived amino acid and have a nitrogen atom in a heterocyclic ring system.
Indolizidiniques alkaloids derived from L-lysine and have a core feature of the indolizidine.
Castanospermine and swansonine acids are indoliziniques.
Properties indoliziniques alkaloids are:
Inhibition of proliferation and tumor dissemination
immunomodulatory action
Stimulating the production of interleukin-2 and T cell proliferation
Activity against retroviruses (HIV), due to the ability to interfere with the functions of the envelope glycoprotein of the virus.
Action against cytomegalovirus (CMV)

Echinacea is so effective because it actually mimics the actions of a chemical the human body produces called interferon, which basically shields cells from viral infection. As an anti-viral, the herb is capable of building-up the body's immune system according to German researchers, by increasing the amount of T-cells, white-blood cells in the body that fight infection, by 30 percent. An article by the University of Pittsburgh called "About Echinacea" goes into further detail about Echinacea A. healing properties, stating that it contains many chemical components such as essential oils, Vitamin B1, B2, and B3, kaempferol, and terpenoids just to name a few, in addition to the natural anti-biotics echinacoside and echinacein, that all allow the plant to neutralize enzymes that invade cells and attack healthy tissues. Echinacea has very complex molecules whose structure is very similar to what is found on the surface of bacteria or other microbes. It is believed that echinacea simulates microbial invasion and alert the entire immune system! It is a bit like an alarm,

Preventing leukopenia caused by radiotherapy or chemotherapy. In the late 1980s, German researchers launched a series of preliminary clinical trials aimed at determining if a preparation containing extracts of Echinacea, wild indigo and white cedar could minimize the adverse effects of radiotherapy, particularly for what is the drop in white blood cells (leukopenia).
Echinacea can also be used externally. Although not normally available commercially, injections and topical use can be helpful in improving skin conditions like herpes lesions, sunburn, eczema and wounds.
Physical Action: Summary
  Traditionally used by American Indians to fight infections (colds, tonsillitis ...), biting snakes, cutannees diseases, intestinal pain, etc.. Today its use is limited mainly to the stimulation of the immune system to treat and prevent infections of upper and lower respiratory tract and other viral, bacterial or fungal infections. It is very popular in Germany and is approved as a treatment support during respiratory infections or urinary tract. Fungal infections as Candida albicans and Listeria, monocytogenes, chronic fatigue syndrome, chronic arthritis, cancer, chronic pelvic infections, etc.. It is also used in topical form in Europe in order to accelerate wound healings due to injuries, burns, herpes or inflammatory disorders (eczema. ..)


How use?
Infusion. : Infuse for 10 minutes, 1 g of roots or dried aerial parts in 1 cup of boiling water. Drink from 1 to 6 per day.
Decoction : Boil for 5 to 10 minutes, 1 g of roots of Echinacea in 1 cup of water. Take up to three cups per day.
Capsules.: Containing only powder capsules for roots or aerial parts, it is recommended to take the equivalent of 1 g, 3 times a day.

NOTE: A report on mayo clinic  suggests that people with autoimmune diseases should consult a physician before using this plant. Be careful with duration of use as a treatment too long, it can cause immuno-suppressant (inversion effect)



References:
Schapowal A, Berger D, et al. Eur J Med Res. 2009 Sep 1;14(9):406-12. Echinacea/sage or chlorhexidine/lidocaine for treating acute sore throats: a randomized double-blind trial
 Linde K, Barrett B, et al. Echinacea for preventing and treating the common cold.Cochrane Database Syst Rev. 2006 Jan 25;(1):CD000530.
Pochernyayeva VF. Echinacea symposium presents new research on Chernobyl victims. 1999 (June); International Echinacea Symposium (Kansas City), American Herbal Products Association.
Freeman C, Spelman K. A critical evaluation of drug interactions with Echinacea spp. Mol Nutr Food Res. 2008 Jul;52(7):789-98. Review.

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